Loctite sets up in the absence of air and the presence of metal ions. Some metals cause the hardening process to occur faster than others, especially copper. Loctite will setup without the primer, I have never used it for any applications. If you want to speed up the hardening process, simply rub a piece of copper wire in the female threads of the chicago screw prior to assembling the fastener, the primer is simply as carrier with copper infused into the mix.