I think name brand designers are always on the lookout for people who do work they would like to include in their products. I've done some business with a couple of them, now, who purchased samples. One saw my web site, and another found me on Etsy.
But at the end of the day, I don't think they can afford us, even if they charge 10 times the amount for the item that we would normally sell it for. I believe it's probably because what they are really selling is the marketing itself. They put all their money into marketing and very little into the manufacture of the product. Even as much as they charge for something, their profit margin isn't as high as you might guess, but they sell a lot more.
On the other hand, most of us either can't afford the kind of marketing they do to creates the mass illusion that is their designer image, or don't have the marketing savvy. Personally, I wouldn't market my products that way even if I did have the savvy and the money, because I believe in selling something that is truly of value, rather than just a bunch of marketing hype. I have a feeling a lot of you feel the same way about it.
I still think there are a few things we can and should do to improve our images as independent makers, though, without spending a lot, and without compromising how we represent ourselves. Put a little more effort into well-designed packaging and tagging. Think of the packaging as part of the product. Take a critical look at the channels you are using to get your product seen, craft fair displays, product literature, etc... Do they look professional, or amateur? Do you have quality images of items you make, or just snapshots? If you have customers telling you what they got was much better than what was pictured, it's probably a sign that you could charge more for your work if you produced better images of it. You can improve them a ton without spending a lot. These all might seem like little things, but if you don't think they matter, think again.
Kate