Hi Vincent,
I won't say for certain because there's much I don't know.
However, I'd see no reason why not. I have a much older 22W156 twin needle that came to me with one needle and I've sewn with it that way. In my case, the second hook was disabled by adjusting the gears apart.
Wait for one of the big dogs to chime in. There may be some downside I don't know about.
Also, why not sign up for an account? It'll make communicating, getting notices of replies and so on much easier.
Welcome aboard.