I have a 4 x 8 foot work table. One corner covered with cutting mats with a 4 ft straightedge attached to the edge to cut long straight pieces of leather. (Leather slips under the straightedge and is clamped to hold it securely while cutting.)
Another corner setup with airbrush and fan/filter for spraying dye and finishes.
Third corner has granite block covered with brown paper - stamping and tooling is done here along with gluing, edge painting, dyeing small pieces and coloring leather. Brown paper makes drips easy to clean up, I just replace the paper when it gets nasty.
4th corner has bench vise and arbor press for stamping and setting rivets, grommets etc. (vise is not normally used for leather, I used to do a lot of woodworking and a vise always comes in handy for holding things.)
4 x 8 ft shelf under the workbench holds plastic storage bins with hardware, threads, tools, dyes, and any other stuff that I don’t use every day.
Sewing machine in another room - keeps it away from dust and dirt. Also have a large table to layout leather to mark for cutting. More often than not, I layout large hides on my pool table - it’s the largest flat area available to work on other than the floor, and my back and knees don’t like working on the floor anymore!
Gary